Cleveland Clinic’s largest-ever building, the 1-million-square-foot Neurological Institute, approaches completion across East 89th Street (Harrison Whittaker). CLICK IMAGES TO ENLARGE THEM.
Progress Pics: Neuro Institute, Innovation District
Since announcing it in 2022, the Cleveland Clinic has neared completion on a massive, $1.3 billion expansion plan. But with a new hotel, inpatient bed tower, lab research facilities, and Level I Trauma Center planned, its next round of expansion projects could be even bigger.
The 1-million-square-foot Neurological Institute will be the Clinic’s largest building ever upon completion. Since NEOtrans’ last construction update in November, the $1.1 billion project has lowered its tower cranes and progressed on the interior buildout.
The structure was designed by Hopkins Architects of London, UK and Stantec, Inc. of Edmonton, Alberta, Canada. Turner Construction is its general contractor.
To account for increased parking needs, the Clinic also intends to build two massive garages on Carnegie Avenue: a 1,500-space East Garage for caregivers northeast of the intersection with East 105th Street, and a 2,500-space West Garage for patients and visitors at East 86th Street.
A research building at the northwest corner of Cedar Avenue and East 100th Street will house specialty research facilities and core services (Harrison Whittaker).
The East Garage is to be built on the site of the Clinic’s vacant, to-be-demolished OS Building, 10861 Carnegie. The West Garage will be constructed on the site of the city’s original Sears, Roebuck and Co. store, built in 1928.
The former Cleveland Play House complex later expanded into the store after Sears closed it in 1980. Both were demolished by the Clinic in 2023. The garages received schematic approval from City Planning Commission on Friday.
On the north side of Cedar Avenue, a pair of medical research buildings are nearing completion on either side of East 100th Street.
The Mukbarak Global Center for Pathogen & Human Health Research will occupy space in the eastern building, while its neighbor to the west will host specialty research facilities and core services.
The structure at right will be home to the Mukbarak Pathogen Center (Harrison Whittaker).
Those research buildings, totaling 296,000 square feet, represent a $420 million investment through the Cleveland Innovation District — a public-private initiative which received $300 million in Clinic funding.
The structures were designed by Cleveland Clinic Buildings + Design, working with HOK Architects of St. Louis and Vanderweil Engineers of Boston. Gilbane Building is managing its construction.
A third project, the $172 million expansion of the Clinic’s Cole Eye Institute, opened in February 2025.
A sign at the southeast corner of Cedar Avenue and East 105th Street reads “Canon Comprehensive Imaging Resource Center: Coming Soon!” (Harrison Whittaker).
In December, NEOtrans detailed a plan to renovate the former IBM Explorys building, 10500 Cedar Ave., into the new headquarters for Canon Healthcare USA.
The facility, called the Comprehensive Imaging Resource Center, will occupy 30,000 square feet of space and employ 50 permanent employees.
Renovation work should already be underway, with signage in front of the building confirming the new facility. Panzica Construction of Mayfield Village is the project’s general contractor.
The former St. Agnes Church site, where a mixed-use development is being planned by Silver Hills Development (Harrison Whittaker).
As the area continues to add jobs, the surrounding Fairfax neighborhood has seen an increase in new residential development.
At the site of the former St. Agnes Church, 8014 Euclid Ave., a new mixed-use residential and retail development by Silver Hills Development Inc. of Shaker Heights is in the early stages of planning.
Called Silver Hills at Euclid Bell Tower, the potential development would rise next to the church’s historic bell tower — the only piece of the structure which remains today.
The Gardens of Fairfax will expand its nursing home, across from the Cleveland Clinic. The Clinic’s Neurological Institute nears completion in the background (Harrison Whittaker).
At the south edge of the Clinic’s campus, a nursing home renovation and expansion is underway at The Gardens of Fairfax, 9014 Cedar Ave.
The expansion will add 84 new private rooms across three phases but required the demolition of a Gilded Age mansion built in 1891. The project’s first phase renovated the existing facility last year, while demolition work for the facility’s expansion was recently completed by KMU Trucking & Excavation LLC of Avon.
For more construction updates around Greater Cleveland, check out NEOtrans’ other Progress Pics articles.
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