CWRU, Clinic projects come close to completion

Looking north on Martin Luther King Jr. Drive, CWRU’s Interdisciplinary Science and Engineering Building has nearly finished its exterior façade (Harrison Whittaker). CLICK IMAGES TO ENLARGE THEM.

Progress Pics: ISEB, Neuro Institute, Monmouth Building, Chick-fil-A, more

Cleveland’s downtown may possess its historic core and central business district, but several massive developments are solidifying Greater University Circle’s status as one of the most important job centers in Northeast Ohio.

The largest of those is the Cleveland Clinic’s 1-million-square foot Neurological Institute, 2083 E. 89th St. Expected to open in early 2027, the 14-story facility includes four outpatient floors, four inpatient floors, and a surgery floor.

The $1.1 billion structure will be the Clinic’s largest building, and it’s most expensive yet — though its next round of expansion projects may prove even more costly.

Cleveland Clinic’s Neurological Institute nears completion on the north side of Carnegie Avenue at East 90th Street (Harrison Whittaker).

The Neurological Institute was designed by Hopkins Architects of London, UK and Stantec, Inc. of Edmonton, Alberta, Canada. Turner Construction is the project’s general contractor.

It will follow the opening of two medical research buildings which wrapped up construction earlier this year on the north side of Cedar Avenue and East 100th Street.

Cleveland Clinic’s OS building, 10681 Cargnegie Ave., is slated for demolition to make way for a 1,500-space parking garage (Harrison Whitaker).

Cleveland Clinic’s next major project involves the construction of two massive parking garages: a 1,500-space East Garage at the northeast corner of Carnegie Avenue and East 105th Street, and a 2,500-space West Garage at the northwest corner of Carnegie and East 86th Street — the site of the demolished Cleveland Play House.

A permit was issued on July 13 for the demolition of the Clinic’s OS building, 10681 Carnegie Ave., to make way for construction of the East Garage. Fencing was spotted around the building shortly after.

In late July, equipment was spotted on the former Cleveland Play House site at the northwest corner of East 86th Street and Carnegie Avenue, where a 2,500-space parking garage is planned (Harrison Whittaker).

Cleveland Clinic isn’t the only institutional player building big in University Circle. On the site of the demolished Yost Hall, Case Western Reserve University (CWRU) is nearing completion on its $300 million Interdisciplinary Science and Engineering Building (ISEB).

The 189,000-square-foot research building will host a variety of labs as well as collaborative gathering areas. It will be the CWRU’s largest structure ever.

ISEB wraps up construction on the southwest side of Case Quad (Harrison Whittaker).

ISEB was designed by HGA Architects of Minneapolis and is being constructed by Discovery Builders — a joint venture between Turner Construction, Next Generation Construction and The AKA Team of Cleveland, and construction staffing firm Adrian Maldonado & Associates of Berea, OH.

The building is expected to open in time for the 2026-27 academic year. In the meantime, construction progress can be viewed via a live webcam.

The historic Monmouth Building is being renovated with new apartments and retail space (Harrison Whittaker).

As University Circle’s employment and education centers continue to grow, demand for new housing and retail are expected to increase with them.

At 11619 Euclid Ave., WXZ Development of suburban Fairview Park is renovating the 1915-built Monmouth Building with 12 apartments and three ground-level storefronts.

The redevelopment project was awarded Ohio Historic Preservation Tax Credits in 2023. Behind it, a new mixed-use building is planned.

The first public-facing Chick-fil-A in the city of Cleveland is expected to open soon in the Uptown District of University Circle (Harrison Whittaker).

Less then 700 feet away, a vacant retail space in the Uptown District will soon be home to Chick-fil-A’s first public-facing retail location in Cleveland proper. Job listings for the new restaurant were spotted last month.

For more construction updates around Greater Cleveland, check out NEOtrans’ other Progress Pics articles.

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